Effect of the Deep Sea Shark-liver Oil Component Food on Secretion Type Immunoglobulin A Density of Saliva in the Normal Man and Woman Adult
Published on 10. April 2015
Effect of the Deep Sea Shark-liver Oil Component Food on Secretion Type Immunoglobulin A Density of Saliva in the Normal Man and Woman Adult
Naobumi Hamadate, Yoshiyuki Matsumoto, Mami Shikura, Chiemi Mizukami, Kayoko Seto, Tetsuro Yamamoto, Hideyo Yamaguchi, Muneaki Iizuka, Etsushi Yamamoto, Sumio Kondo, Kazunaga Yazawa
ABSTRACT:
Secretory immunoglobulin A (s-IgA) in saliva constitutes the first-line barrier to the entry of pathogens into the body, implying its critical role in mucosal immunity. To examine the effect of a shark liver oil (SLO)-containing diet on salivary s-IgA concentration in healthy male and female adults, 42 subjects were assigned to either placebo or 6 weeks of a 2,400 mg SLO-containing diet (1,500 mg as SLO) and assessed in a randomized, double-blind, placebo-controlled, parallel group trial. Salivary s-IgA concentration significantly increased at week 6 in the SLO group (P = 0.033), but not in the placebo group. Moreover, there was a significant difference between groups in the magnitude of change from baseline to week 6. No intervention-related adverse event or abnormal changes of laboratory test parameters were observed throughout the study period. In conclusion, an SLO-containing diet increases salivary s-IgA in healthy adults.
Japanese Journal of Complementary and Alternative Medicine Vol. 12 (2015) No. 1 p. 45-49